Peninsula Compounding Pharmacy can help with many health issues that affect women of all ages. If your patients have concerns about:
- Aging skin and dark spots
- Hair loss
- Vaginal infections, dryness, and pain
- Hormone changes
- Aches and pains
- Low libido
- Fungal infections
- Mental Health
- Breast feeding
- Weight management
Then we’re here to help! Peninsula Compounding Pharmacy can help create customized treatment options for these and many other health issues.
Digestion, appetite, immune function, brain function, libido, and mood are all influenced by hormones. Indeed, hormones control nearly all the body’s basic tasks.
Low or imbalanced hormone levels can have uncomfortable effects on your patient’s health and feeling of well-being. For more and more people experiencing difficulties with low or imbalanced hormones, the solution is bioidentical hormone replacement therapy. This is the use of medications to replace the hormones the body isn’t producing.
Bioidentical hormones act the same as natural human hormones. Thus, they help to mend a hormonal imbalance with hormones that are identical to those produced in the human body.
Bioidentical hormones are different from those used in traditional hormone replacement therapy. Did you know that traditional hormone replacement therapy (medications from a retail pharmacy) sometimes uses hormones made from the urine of pregnant horses (or other synthetic hormones)? Yikes! Bioidentical hormones, which are man-made from plant estrogens, have the same molecular structure and act the same as natural human hormones. We’ll take plants over synthetics any day!
There are many of benefits to bioidentical hormone replacement therapy. Take a look below.
Benefits of Bio-identical Hormone Replacement for Women
BHRT is most often prescribed to ease the symptoms of menopause, but it also can be used to ease a variety of conditions that women of all ages may experience. Here’s why we think it’s a great option. It has been shown to:
- Ease pre-menstrual syndrome (PMS)
- Regularize irregular menstrual cycles
- Assist with issues of infertility
- Prevent hot flashes
- Decrease night sweats
- Boost sex drive
- Make sexual intercourse less painful
- Maintain vaginal health and lubrication
- Stabilize mood
- Ameliorate post-partum depression
- Combat weight gain
- Ease endometriosis
- Ease fibrocystic breasts
- Improve sleep
- Prevent bone loss
Research and Application of BioIdentical Hormone Replacement Therapy for Women
Ruiz A, Daniels K, Barner J, Carson J, Frei C. Effectiveness of Compounded Bioidentical Hormone Replacement Therapy: An Observational Cohort Study. BMC Women’s Health, 2011; 11(1).
Holtorf K. The Bioidentical Hormone Debate: Are Bioidentical Hormones (Estradiol, Estriol, and Progesterone) Safer or More Efficacious than Commonly Used Synthetic Versions in Hormone Replacement Therapy? Postgraduate Medicine, 2009; 121(1):73-85.
Schwartz E, Holtorf K, Brownstein D. The Truth About Hormone Therapy. The Wall Street Journal, March 16, 2009: A17.
Klaiber E, Vogel W, Rako S. A critique of the Women’s Health Initiative hormone therapy study. Fertility and Sterility, 2005; 84(6):1589-1601.
Fait T. Menopause hormone therapy: latest developments and clinical practice. Drugs Context, 2019; 8:212551.
Bae JM, Yoon BK. The Role of Menopausal Hormone Therapy in Reducing All-cause Mortality in Postmenopausal Women Younger than 60 Years: An Adaptive Meta-analysis. J Menopausal Med, 2018; 24(3):139-142.
Thompson JJ, Ritenbaugh C, Nichter M. Why women choose compounded bioidentical hormone therapy: lessons from a qualitative study of menopausal decision-making. BMC Womens Health, 2017;17(1):97.
Rech CM, Clapauch R, de Souza Md, Bouskela E. Low testosterone levels are associated with endothelial dysfunction in oophorectomized early postmenopausal women. Eur J Endocrinol, 2016; 174(3):297-306.
Ruiz A, Daniels K. The effectiveness of sublingual and topical compounded bioidentical hormone replacement therapy in postmenopausal women: an observational cohort study. Int J Pharm Compd, 2014; 18(1):70-77.
Stephenson K, Neuenschwande P, Kurdowska A. The effects of compounded bioidentical transdermal hormone therapy on hemostatic, inflammatory, immune factors; cardiovascular biomarkers; quality-of-life measures; and health outcomes in perimenopausal and postmenopausal women. Int J Pharm Compd, 2013; 17(1):74-85.
Marjoribanks J, Farquhar C, Roberts H, Lethaby A. Long term hormone therapy for perimenopausal and postmenopausal women. Cochrane Database Syst Rev, 2012; (7):CD004143.
Ettinger B, Friedman G, Bush T, Qusenberry Jr C. Reduced Mortality Associated With Long-Term Postmenopausal Estrogen Therapy. Obstetrics & Gynecology, 1996; 87(1):6-12.
Gordhandas S, Norquist BM, Pennington KP, et al. Hormone replacement therapy after risk reducing salpingo-oophorectomy in patients with BRCA1 or BRCA2 mutations; a systematic review of risks and benefits. Gynecol Oncol, 2019, pii: S0090-8258(18)31514-2.
Marchetti C, De Felice F, Boccia S, et al. Hormone replacement therapy after prophylactic risk-reducing salpingo-oophorectomy and breast cancer risk in BRCA1 and BRCA2 mutation carriers: A meta-analysis. Crit Rev Oncol Hematol, 2018; 132:111-115.
Colditz G, Hankinson S, Hunter D, et al. The use of estrogens and progestins and the risk of breast cancer in postmenopausal women. The Endocrinologist, 1995; 5(6):441-442.
Zilio Rech CM, Clapauch R, Bouskela E. Sexual Function Under Adequate Estrogen Therapy in Women After Oophorectomy Versus Natural Menopause. J Womens Health (Larchmt), 2019: doi: 10.1089/jwh.2017.6905
Labrie F, Archer D, Bouchard C, et al. Intravaginal dehydroepiandrosterone (prasterone), a highly efficient treatment of dyspareunia. Climacteric, 2011; 14(2):282-288.
Labrie F, Archer DF, Koltun W et al. Efficacy of intravaginal dehydroepiandrosterone (DHEA) on moderate to severe dyspareunia and vaginal dryness, symptoms of vulvovaginal atrophy, and of the genitourinary syndrome of menopause. Menopause, 2018; 25(11):1339-1353.
Kushnir VA, Darmon SK, Barad DH, Weghofer A, Gleicher N. Effects of dehydroepiandrosterone (DHEA) supplementation on sexual function in premenopausal infertile women. Endocrine, 2018; doi: 10.1007/s12020-018-1781-3.
Labrie F, Archer D, Bouchard C, et al. Effect of intravaginal dehydroepiandrosterone (Prasterone) on libido and sexual dysfunction in postmenopausal women. Menopause, 2009; 16(5):923-931.
Arlt W, Callies F, Allolio B. Dhea Replacement in Women with Adrenal Insufficiency—Pharmacokinetics, Bioconversion and Clinical Effects on Well-Being, Sexuality and Cognition. Endocr Res, 2000; 26(4):505-511.
Sbisa A, van den Buuse M, Gogos A. The effect of estrogenic compounds on psychosis-like behaviour in female rats. PLoS One, 2018;13(3):e0193853.
Khan MM. Translational Significance of Selective Estrogen Receptor Modulators in Psychiatric Disorders. Int J Endocrinol, 2018; 2018:9516592.
Del Río JP, Alliende MI, Molina N et al. Steroid Hormones and Their Action in Women’s Brains: The Importance of Hormonal Balance. Front Public Health, 2018; 6:141.
Kulkarni J. Perimenopausal depression – an under-recognised entity. Aust Prescr, 2018; 41(6):183-185.
Kulkarni J, Gavrilidis E, Wang W. Estradiol for treatment-resistant schizophrenia: a large-scale randomized-controlled trial in women of child-bearing age. Mol Psychiatry, 2015; 20(6):695-702.
do Vale S, Selinger L, Martins JM. Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone-sulfate (DHEAS) and emotional processing – A behavioral and electrophysiological approach. Horm Behav, 2015; 73:94-103.
Ruiz AD, Daniels KR, Barner JC, Carson JJ, Frei CR. Effectiveness of compounded bioidentical hormone replacement therapy: an observational cohort study. BMC Womens Health, 2011; 11:27.
Graziottin A, Serafini A. Depression and the menopause: why antidepressants are not enough? Menopause Int, 2009; 15(2):76-81.
Wang W, Liu H, Li J, et al. Effect of preconceptional DHEA treatment on in vitro fertilization outcome in poor ovarian respond women: study protocol for a randomized controlled trial. Trials, 2019; 20(1):50.
Chern CU, Tsui KH, Vitale SG. Dehydroepiandrosterone (DHEA) supplementation improves in vitro fertilization outcomes of poor ovarian responders, especially in women with low serum concentration of DHEA-S: a retrospective cohort study. Reprod Biol Endocrinol, 2018; 16(1):90.
Barad D, Gleicher N. Effect of dehydroepiandrosterone on oocyte and embryo yields, embryo grade and cell number in IVF. Human Reproduction, 2006; 21(11):2845-2849.
Barad D, Gleicher N. Increased oocyte production after treatment with dehydroepiandrosterone. Fertility and Sterility, 2005; 84(3):756.e1-756.e3.
Metabolism and Obesity
Villareal D, Holloszy J. Effect of DHEA on Abdominal Fat and Insulin Action in Elderly Women and Men. JAMA, 2004; 292(18):2243.
Davis S, Walker K, Strauss B. Effects of estradiol with and without testosterone on body composition and relationships with lipids in postmenopausal women. Menopause, 2000; 7(6):395-401.
do Vale S, Selinger L, Martins JM. Hormonal modulation of novelty processing in women: Enhanced under working memory load with high dehydroepiandrosterone-sulfate-to-dehydroepiandrosterone ratios. Neurosci Lett, 2016; 634:98-103.
Carroll JC, Rosario ER. The potential use of hormone-based therapeutics for the treatment of Alzheimer’s disease. Curr Alzheimer Res, 2012; 9(1):18-34.
Pike CJ, Carroll JC, Rosario ER, Barron AM. Protective actions of sex steroid hormones in Alzheimer’s disease. Front Neuroendocrinol, 2009; 30(2):239-58.
Anderson G. Hormone Replacement Therapy May Protect Against Eye Disease. American Academy of Ophthalmology website. https://www.aao.org/newsroom/news-releases/detail/hormone-replacement-therapy-may-protect-against-ey. November 13, 2017. Accessed January 24, 2019
Jankowski CM, Wolfe P, Schmiege SJ. Sex-specific effects of dehydroepiandrosterone (DHEA) on bone mineral density and body composition: A pooled analysis of four clinical trials. Clin Endocrinol (Oxf), 2019; 90(2):293-300.
Prior JC, Seifert-Klauss VR, Giustini D, et al. Estrogen-progestin therapy causes a greater increase in spinal bone mineral density than estrogen therapy – a systematic review and meta-analysis of controlled trials with direct randomization. J Musculoskelet Neuronal Interact, 2017; 17(3):146-154.
Jankowski C, Gozansky W, Kittelson J, et al. Increases in Bone Mineral Density in Response to Oral Dehydroepiandrosterone Replacement in Older Adults Appear to Be Mediated by Serum Estrogens. The Journal of Clinical Endocrinology & Metabolism, 2008; 93(12):4767- 4773.
Artero-Morales M, González-Rodríguez S, Ferrer-Montiel A. TRP Channels as Potential Targets for Sex-Related Differences in Migraine Pain. Front Mol Biosci, 2018; 5:73.
Yousefi B, Rastin M, Hatef MR, et al. In vitro modulatory effect of dehydroepiandrosterone sulfate on apoptosis and expression of apoptosis-related genes in patients with systemic lupus erythematosus. J Cell Physiol, 2018; doi: 10.1002/jcp.27878.
Collomp K, Gravisse N, Vibarel-Rebot N. Neuroendocrine and inflammatory responses to DHEA administration in young healthy women. Pharmacol Biochem Behav, 2018;175:19-23.