Prescribing for Mens Health & Hormone Therapy - Peninsula Compounding Pharmacy

Compounding pharmacists can help with many health issues that affect men of all ages.

Many men have concerns about:

Depression
Hair loss
Aging skin
Erectile dysfunction
Low libido
Aches and pains
Fungal infections, such as athlete’s foot or jock itch
Excessive sweating

A Peninsula Compounding Pharmacy can create customized treatment options for these and many other health issues

Testosterone Therapy

Digestion, appetite, immune function, brain function, libido, and mood are all influenced by hormones? Indeed, hormones control nearly all the body’s basic tasks.

Low or imbalanced hormone levels can have uncomfortable effects on a patient’s health and their feeling of well-being. For more and more people experiencing difficulties with low or imbalanced hormones, the solution is bioidentical hormone replacement therapy. This is the use of medications to replace the hormones that the body isn’t producing.

Bioidentical hormones act the same as natural human hormones. Thus, they help to mend a hormonal imbalance with hormones that are identical to those produced in the human body.

In men, Hormone Replacement Therapy is most commonly used to treat the symptoms of andropause, an age-related decline in male hormone levels sometimes, called testosterone deficiency. Although it is roughly similar to menopause in women, the decrease in hormones and onset of symptoms in men is slower and subtler than it is in women. Low testosterone levels can occur for many reasons, however, and at any age, even as early as the teenage years.

BIO-IDENTICAL HORMONE REPLACEMENT FOR MEN MAY HELP:

Increase energy and motivation
Boost sex drive
Combat erectile dysfunction
Reduce fat, build muscle
Improve sleep
Reduce irritability
Stabilize mood, improve depression and anxiety
Enhance memory and concentration
Strengthen bones to prevent fractures in later years
Lower the risk of heart disease

Research and Application of Bio-identical Hormone Replacement Therapy in Men

Clinical Practice

Loria K. Polycythemia risk evaluated in patients on TRT pellets. Urology Times website. http://urologytimes.modernmedicine.com/urology-times/news/polycythemia-risk-evaluated-patients-trt-pellets?page=0,1. December 06, 2016. Accessed January 24, 2019.

Schwartz E, Holtorf K, Brownstein D. The Truth About Hormone Therapy. The Wall Street Journal, March 06, 2016:A17.Morley J. The benefits and risks of testosterone replacement therapy: a review. Therapeutics and Clinical Risk Management, 2009; 5:427-448.

Metabolic Syndrom

Shigehara K, Konaka H, Nohara T, et al. Effects of testosterone replacement therapy on metabolic syndrome among Japanese hypogonadal men: A subanalysis of a prospective randomised controlled trial (EARTH study). Andrologia, 2018; 50(1).

Rubinow KB. Estrogens and Body Weight Regulation in Men. Adv Exp Med Biol, 2017; 1043:285-313.Kelly D, Jones T. Testosterone: a metabolic hormone in health and disease. Journal of Endocrinology, 2013; 217(3):R25-R45.

Muraleedharan V, Hugh Jones T. Testosterone and the metabolic syndrome. Ther Adv Endocrinol Metab, 2013; 1(5):207–223.

Diabetes

Haider A, Haider K, Saad F, Hanefeld M. Remission of type 2 diabetes and pleiotropic effects of long-term testosterone treatment for “late-onset” hypogonadism: A case report. SAGE Open Med Case Rep, 2019; 7:2050313X18823454.

Groti K, Žuran I, Antonič B, Foršnarič L, Pfeifer M. The impact of testosterone replacement therapy on glycemic control, vascular function, and components of the metabolic syndrome in obese hypogonadal men with type 2 diabetes. Aging Male, 2018; 21(3):158-169.

Magnussen LV, Hvid LG, Hermann AP, et al. Testosterone therapy preserves muscle strength and power in aging men with type 2 diabetes-a randomized controlled trial. Andrology, 2017; 5(5):946-953.

Magnussen LV, Glintborg D, Hermann P, et al. Effect of testosterone on insulin sensitivity, oxidative metabolism and body composition in aging men with type 2 diabetes on metformin monotherapy. Diabetes Obes Metab, 2016; 18(10):980-9.

Giagulli VA, Carbone MD, Ramunni MI, et al. Adding liraglutide to lifestyle changes, metformin and testosterone therapy boosts erectile function in diabetic obese men with overt hypogonadism. Andrology, 2015; 3(6):1094-103.

Brooke JC, Walter DJ, Kapoor D, et al. Testosterone deficiency and severity of erectile dysfunction are independently associated with reduced quality of life in men with type 2 diabetes. Andrology, 2014; 2(2):205-211.

Mitkov MD, Aleksandrova IY, Orbetzova MM. Effect of transdermal testosterone or alpha-lipoic acid on erectile dysfunction and quality of life in patients with type 2 diabetes mellitus. Folia Med (Plovdiv), 2013; 55(1):55-63.

Muraleedharan V, Marsh H, Kapoor D, Channer K, Jones T. Testosterone deficiency is associated with increased risk of mortality and testosterone replacement improves survival in men with type 2 diabetes. European Journal of Endocrinology, 2013; 169(6):725-733.

Mortality

Sharma R, Oni O, Gupta K, et al. Normalization of testosterone level is associated with reduced incidence of myocardial infarction and mortality in men. Eur Heart J, 2015; 36(40):2706-2715.

Comhaire F. Hormone replacement therapy and longevity. Andrologia, 2015; 48(1): 65-68.

Shores M, Smith N, Forsberg C, Anawalt B, Matsumoto A. Testosterone Treatment and Mortality in Men with Low Testosterone Levels. The Journal of Clinical Endocrinology & Metabolism, 2012; 97(6):2050-2058.

Laughlin G, Barrett-Connor E, Bergstrom J. Low Serum Testosterone and Mortality in Older Men. The Journal of Clinical Endocrinology & Metabolism, 2008; 93(1):68-75.

Khaw K, Dowsett M, Folkerd E, et al. Endogenous Testosterone and Mortality Due to All Causes, Cardiovascular Disease, and Cancer in Men: European Prospective Investigation Into Cancer in Norfolk (EPIC-Norfolk) Prospective Population Study. Circulation, 2007; 116(23):2694-2701.

Cancer

Roddam A, Allen N, Appleby P, Key T. Endogenous Sex Hormones and Prostate Cancer: A Collaborative Analysis of 18 Prospective Studies. Journal of the National Cancer Institute, 2008; 100(3):170-183.

Rhoden E, Morgentaler A. Testosterone Replacement Therapy in Hypogonadal Men at High Risk for Prostate Cancer: Results of 1 Year of Treatment in Men With Prostatic Intraepithelial Neoplasia. The Journal of Urology, 2003; 170(6):2348-2351.

DHEA

Villareal D, Holloszy J. Effect of DHEA on Abdominal Fat and Insulin Action in Elderly Women and Men. JAMA, 2004; 292(18):2243.

Oberbeck R, Dahlweid M, Koch R, et al. Dehydroepiandrosterone decreases mortality rate and improves cellular immune function during polymicrobial sepsis. Critical Care Medicine, 2001; 29(2):380-384.

Wolkowitz O, Reus V, Keebler A, Nelson N, Friedland M. Double-Blind Treatment of Major Depression with Dehydroepiandrosterone. The American Journal of Psychiatry, 1999; 156(4):646-649.

Anti-Aging

Magnussen LV, Hvid LG, Hermann AP, et al. Testosterone therapy preserves muscle strength and power in aging men with type 2 diabetes-a randomized controlled trial. Andrology, 2017; 5(5):946-953.

Comhaire F. Hormone replacement therapy and longevity. Andrologia, 2016; 48(1):65-8.

Frederiksen L, Højlund K, Hougaard DM, Brixen K, Andersen M. Testosterone therapy increased muscle mass and lipid oxidation in aging men. Age (Dordr), 2012; 34(1):145-56.

Sexual Function

Rosen RC, Wu F, Behre HM, et al. Quality of Life and Sexual Function Benefits of Long-Term Testosterone Treatment: Longitudinal Results From the Registry of Hypogonadism in Men (RHYME). J Sex Med, 2017;14(9):1104-1115.

Corona G, Rastrelli G, Morgentaler A, et al. Meta-analysis of Results of Testosterone Therapy on Sexual Function Based on International Index of Erectile Function Scores. Eur Urol, 2017; 72(6):1000-1011.

Hackett G, Cole N, Saghir A, et al. Testosterone undecanoate improves sexual function in men with type 2 diabetes and severe hypogonadism: results from a 30-week randomized placebo-controlled study. BJU Int, 2016; 118(5):804-813.

Cardiovascular

Chrysant SG. Controversies regarding the cardiovascular effects of testosterone replacement therapy in older men. Drugs Today (Barc), 2018; 54(1):25-34.

Neuromuscular

Recovery Otzel DM, Lee J, Ye F, Borst SE, Yarrow JF. Activity-Based Physical Rehabilitation with Adjuvant Testosterone to Promote Neuromuscular Recovery after Spinal Cord Injury. Int J Mol Sci, 2018;19(6).